Severe mental disorders like schizophrenia are a leading cause of disability in people in the prime years of their lives (aged 15 to 44 years). Relapse is a primary contributor to schizophrenia disease burden and is frequently attributed to medication noncompliance and inadequate doses. Currently, a patient?s neuroleptic dose is titrated to clinical response within recommended dose ranges. Use of unbiased biomarkers of efective neuroleptic treatment-response would greatly facilitate the identifcation of a person?s lowest efective dose to minimize unsafe side efects and improve compliance. Biomarkers may allow precisely tailored adjustments of neuroleptic dose to reduce relapse due to variable disease course.