Protein Targeting and Translocation (ebook)

Argumento de Protein Targeting and Translocation (ebook)

Protein targeting is a fast-moving field that has encompassed areas from biophysics to molecular biology to try to gain insight into how proteins are directed to their final functional location and how such macromolecules are able to cross semi-permeable membrane barriers during their journey. This text reviews our current state of knowledge regarding the interaction of proteins at the membrane interface and the assembly of proteins into biological membranes, before proceeding to look at targeting pathways in both prokaryotic and eukaryotic systems. The reviews have been written by some of the leading researchers in the field, with contributions from around the world and with more than 1,800 references. The text is aimed at graduate students and at researchers with an interest in protein targeting, but may also be of use to final-year undergraduates.

Originally published in 1999.

The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These paperback editions preserve the original texts of these important books while presenting them in durable paperback editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.0Preface Abbreviations Membrane interactions 1 Biophysics of the membrane interface and its involvement in protein targeting and translocation 1 2 Amphiphilic [alpha]-helices and lipid interactions 19 3 Signal sequences: initiators of protein translocation 37 4 Determinants of membrane protein topology and membrane anchoring 49 5 Insertion of single- and multi-spanning proteins into the bacterial cytoplasmic membrane 67 6 Prokaryotic protein translocation 85 7 Protein traffic from the cytosol to the outer membrane of Escherichia coli 105 8 sec-dependent prokaryotic protein secretion 121 9 Targeting and assembly of fimbriae 143 10 Targeting to and translocation across the endoplasmic reticulum membrane 169 11 Protein localization to the endoplasmic reticulum and Golgi complex 193 12 Import and export of proteins at the nucleus 213 13 Mitochondrial targeting and import 231 14 Translocation of proteins into and across the thylakoid membrane 249 15 Principles of peroxisomal protein sorting and assembly 259 16 Targeting of glyoxysomal proteins 273 Subject index 287