This companion to Brenner and Rector's The Kidney offers a state-of-the-art summary of the most recent advances in renal genetics. Molecular and Genetic Basis for Renal Disease provides the nephrologist with a comprehensive look at modern investigative tools in nephrology research today, and reviews the molecular pathophysiology of the nephron as well as the most common genetic and acquired renal diseases. A comprehensive clinical review of Medelian renal disease is also be included.
Detailed review of the molecular anatomy and pathophysiology of the nephron that provides relevant basic science to consider when diagnosing and managing patients with these disorders. 1. The impact of Genetics and Genomics on Renal Science and Renal Medicine, Martin Pollak, David Mount 2. Manipulation of the Mouse Genome: Studying Renal Function and Disease, Alexander Gawlik, Susan E. Quaggin 3. Cardiorenal Physiology of the Mouse: From Loss of Genome to Gain of Phenome, Jurgen Schnermann, John N. Lorenz, Josie P. Briggs 4. Murine Modeling of Kidney Development, Jordan A. Kreidberg II. GENETIC DISORDERS OF RENAL GROWTH AND STRUCTURE 5. Hereditary Disorders of Renal and Urogenital Development, Susan M. Kiefer, Sabiha M. Hussain, Michael Rauchman 6. Autosomal Polycystic Kidney Disease (ADPKD), Jing Zhou, York Pei 7. Autosomal Recessive Polycystic Kidney Disease (ARPKD), Peter C. Harris, Vincente E. Torres 8. Pathogenesis of Nephronophthisis and Medullary Cystic Kidney Disease Thomas Benzing, Gerd Walz III. GENETIC DISORDERS OF RENAL FUNCTION 9. Hereditary Nephroses, Martin Pollak 10. Molecular and Genetic Basis of Alport Syndrome, Sai Ram Keithi-Reddy, Raghu Kalluri 11. Nail-Patella Syndrome, Ralph Witzgall 12. Primary Hyperoxalurias: Molecular and Clinical Insights, Carla F. Monico, Gillian Rumbsy, Dawn S. Milliner 13. Fabry Disease, James A. Shayman , Paul D. Killen 14. Hereditary Disorders of the Proximal Tubule, David Mount 15. Hereditary Disorders of the Thick Ascending Limb and Distal Convoluted Tubule, Martin Konrad, Rodo O. von Vigier, Siegfried Waldegger 16. Hereditary Disorders of Distal Nephron Sodium and Potassium Transport, David Elisson, Christie Thomas 17. Hereditary Renal Tubular Acidosis, Christine E. Kurschat, Seth L. Alper 18. Hereditary Causes of Nephrogenic Diabetes Insipidus, Peter M.T. Deen, Joris H. Robben, Nine V.A.M. Knoers 19. Genetic Disorders of Calcium and Phosphate Homeostasis. Harald W. Jueppner, Rajesh V. Thakker 20. Genetics and Renal Pathophysiology of Essential Hypertension, Pedro A. José, John E. Jones, Scott M. Williams, Gilbert M. Eisner, Robin A. Felder IV. ACQUIRED AND POLYGENIC RENAL DISEASE 21. Molecular Mechanisms of Proteinuria, J. Ashley Jefferson, Stuart J. Shankland 22. Diabetic Nephropathy, Matthew Breyer, Raymond Harris 23. Pathogenesis of HIV-Associated Nephropathy, Michael J. Ross, Paul E. Klotman 24. Pathogenesis of Paraproteinemic Renal Disease, Paul W. Sanders 25. Preeclampsia, Sharon Maynard, S. Ananth Karumanchi 26. Molecular Insights into the Thrombotic Microangiopathies, Charles C. Matouk, Philip A. Marsden 27. IgA nephropathy, Steve Hsu 28. Glomerulonephritis Caused by Antineutrophil Cytoplasmic autoantibodies (ANCA), Gloria A. Preston, Ronald J. Falk 29. Systemic Lupus erythematosus and the Kidney, Vicki Rubin Kelly, Laurence Morel, Mary H. Foster 30. Acute Tubular Necrosis, Joe Bonventre