Pharmacologic options have exploded in recent years, forcing updates and creation of guidelines for their use in a near-simultaneous manner. While some nurses may encounter these new medications at the bedside, drugs with little or no indications in specific arenas may remain unknown to the nurse practicing in a specialized area. This issue of Nursing Clinics of North America offers a broad review of current pharmacologic therapy. Bedside applications (e.g., electronic apps) offering real-time information and updates for clinicians will be highlighted throughout the issue.