The arteries to the upper extremities can be involved at multiple levels by a variety of diseases. Because of the critical sensitivity of motor function and sensation in the arms and hands, minor degrees of ischemia can have major clinical significance. It is essential to understand the exact pathologic process and the sites of involvement to provide proper therapy. This issue will include articles such as: The diagnosis of vaso-occlusive disease within the hand, Botox in the management of vascospastic disorders, Vascular injuries in sports activities, Present options for the management of hypothenar hammer syndrome and many more!