This issue of Critical Care Clinics focuses on Neurocritical Care and covers topics such as: The Evolution of Neurocritical Care, Update in management of acute ischemic stroke, Intracerebral hemorrhage, Subarachnoid treatment, Intracranial pressure monitoring and management of intracranial hypertension, Status Epilepticus, Brain Resuscitation and Prognosis after Cardiac Arrest, Neuromuscular complications of Critical Illness, Adverse Neurological Effects of Commonly Used ICU medications, and Brain death and management of a potential organ donor.