Essentials of Biopharmaceutics and Pharmacokinetics - E-book (ebook)

Argumento de Essentials of Biopharmaceutics and Pharmacokinetics - E-book (ebook)

Essentials of Biopharmaceutics and Pharmacokinetics

Kar?s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically.

The book interrelates five different sections:

Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean?

Section 2 Biopharmaceutics

Section 3 Pharmacokinetics

Section 4 Clinical Pharmacokinetics

Section 5 Bioavailability and Bioequivalence

Each section starts with a basic theory and fields of application, focuses on model-independent pharmacokinetic analyses, expatiates various biopharmaceutical aspects of dosage form and evaluation, provides an altogether new approach in understanding both dosage regimen design and individualization, and explains modification in drug molecules related to the pharmacokinetics.

Undoubtedly, the unique blend of fundamental principles and latest breakthroughs in the field will certainly provide sufficient subject matter to the students of pharmacy, pharmacology, medicinal chemistry scientists, who need a simple as well as detailed introduction in theory and application.0CONTENTS

Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? 1

Chapter 1 Introduction to Biopharmaceutics and Pharmacokinetics 3

1. Introduction 3

2. Historical Perspective of Biopharmaceutics 3

3. Extravascular Administration of a Drug 6

4. Scope of Biopharmaceutics 7

5. Variants in Biopharmaceutics 7

6. Pharmacokinetics 8

7. Clinical Pharmacokinetics 10

8. Pharmacodynamics 12

9. Toxicokinetics and Clinical Toxicology 13

10. Bioavailability 13

11. Bioequivalence 17

Section 2 Biopharmaceutics 23

Chapter 2 Biopharmaceutics 25

1. Introduction 25

2. Biopharmaceutics Classifi cation System (BCS) 29

3. In Vitro?In Vivo Correlation (IVIVC): An Introspection 30

4. Passage of Drugs across Biological Barrier 33

5. Factors Infl uencing Drug Absorption 43

6. Mechanisms of Drug Absorption 58

7. Drug Absorption vs. Bioavailability 72

Section 3 Pharmacokinetics 121

Chapter 3 Pharmacokinetics 123

1. Introduction 123

2. Clinical Signifi cance of Plasma Protein Drug Concentration

Measurement 124

3. Pharmacokinetic Models 133

4. Pharmacokinetics of Drug Absorption 154

5. Volume of Distribution and Distribution Coeffi cient 170

6. Organ-Specifi c Clearance 173

7. Non-Linear Pharmacokinetics 195

8. Pharmacokinetic Profi les of Some Specifi c Examples

from Various Classes of Drugs 206

Section 4 Clinical Pharmacokinetics 215

Chapter 4 Clinical Pharmacokinetics 217

1. Introduction 217

2. Dosage Regimens: Design, Modalities and Implementation 221

3. Single Dose Bioequivalence Study: Design and Relevant Statistics 248

4. Pharmacokinetic Drug Interaction: Signifi cance in Combination Therapy 275

Section 5 Bioavailability and Bioequivalence 283

Chapter 5 Bioavailability and Bioequivalence 285

1. Introduction 285

2. Bioavailability 291

3. Bioequivalence 327

4. Bioanalytical Method Development and Validation for Bioavailability and Bioequivalence Studies 336

Index 347