This issue of Interventional Cardiology Clinics covers congenital and structural heart disease. Expert authors review the most current information available about treating a variety of conditions, including coarctation of the aorta, transcatheter pulmonary valve replacement, percutaneous mitral valve interventions, and catheter interventions for pulmonary artery stenosis. Complex interventions for adults with congenital heart disease are also discussed. Keep up-to-the-minute with the latest developments in this important aspect of interventional cardiology practice.